Abstract
The effect of Cimetidine 1600 mg. daily for three months on prolactin and related
hormones is reported. Basal prolactin levels rose slightly but not significantly.
There was no change in basal thyroid and sex hormone levels nor in the prolactin,
gonadotropin or thyrotrophs responses to releasing hormone stimulation.
Since intravenous Cimetidine induces a transient hyperprolactinemia it appears that
Cimetidine may facilitate release of prolactin but has no effect on its synthesis.
Key words
Cimetidine - Prolactin - Pituitary - Thyroid - Gonads
