Cimetidine Effects on Prolactin Release and Production

S. G. Barber; A. M. Hoare

doi:10.1055/s-0028-1092712

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Horm Metab Res 1979; 11(3): 220-221
DOI: 10.1055/s-0028-1092712

Originals

Cimetidine Effects on Prolactin Release and Production

S. G. Barber , A. M. Hoare

Department of Medicine, University of Birmingham and Wycombe General Hospital, Bucks, United Kingdom

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Publication History

Publication Date:
17 December 2008 (online)

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Abstract

The effect of Cimetidine 1600 mg. daily for three months on prolactin and related hormones is reported. Basal prolactin levels rose slightly but not significantly. There was no change in basal thyroid and sex hormone levels nor in the prolactin, gonadotropin or thyrotrophs responses to releasing hormone stimulation.

Since intravenous Cimetidine induces a transient hyperprolactinemia it appears that Cimetidine may facilitate release of prolactin but has no effect on its synthesis.

Key words

Cimetidine - Prolactin - Pituitary - Thyroid - Gonads